C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/51 (2006.01) C07K 16/28 (2006.01) C07K 16/44 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12N 15/18 (2006.01) C12N 15/67 (2006.01)
Patent
CA 2171759
Disclosed herein are improved methods and compositions for achieving enhanced protein production expressed from non-native gene constructs, including single chain sFv and derivative sequences. The methods and compositions are particularly useful for creating stably transfected, constitutively expressing immortalized mammalian cell lines that exhibit high recombinant protein productivity while maintaining a low copy number per cell of the non-native recombinant DNA sequence encoding the protein of interest.
Procédés et compositions améliorées permettant d'obtenir une production accrue de protéines exprimées par des produits d'assemblage de gènes non natifs, incluant des sFv à chaîne unique et des séquences de dérivés. Lesdits procédés et compositions s'avèrent particulièrement utiles pour créer des lignées cellulaires immortalisées de mammifères à transfection stable et à expression continue, présentant une forte productivité de protéines de recombinaison tout en conservant par cellule un faible nombre de copies de la séquence non native d'ADN de recombinaison codant la protéine d'intérêt.
Dorai Haimanti
Kaplan Paul
Oppermann Hermann
Blake Cassels & Graydon Llp
Creative Biomolecules Inc.
Stryker Corporation
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