Methods and compositions for identifying a protease

Details Methods and compositions for identifying a protease Methods and compositions for identifying a protease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/15 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 9/50 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/867 (2006.01) C12P 21/06 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2401623

Methods are disclosed whereby protease activity is directly linked to replication of viral display packages containing protease-encoding polynucleotides in target cells. The methods can be used, inter alia, to identify proteases, including previously undiscovered proteases or variants of known proteases which may have altered substrate specificity.

L'invention concerne des procédés dans lesquels l'activité d'une protéase est directement mise en relation avec la réplication de capsides de présentation virale contenant des polynucléotides codant pour une protéase dans des cellules cibles. Ces procédés peuvent servir notamment à identifier des protéases, y compris des protéases encore inconnues ou des variants de protéases connues qui peuvent présenter une spécificité de substrat modifiée.

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