Methods and compositions for identifying biomarkers useful...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12P 19/34 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2620521

The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological state. The biomarkers and polymorphisms identified find use in diagnostic and treatment approaches, e.g., some embodiments the invention provide methods and kits for detecting bronchogenic carcinoma and risks thereof.

La présente invention concerne des procédés et des compositions permettant d~identifier des biomarqueurs indiquant un état biologique, en particulier des biomarqueurs de facteur de transcription et des gènes pouvant être régulés par de tels biomarqueurs de facteur de transcription. L'invention concerne également l~identification de polymorphismes dans de tels facteurs de transcription et gènes régulés indicatifs de l~état biologique. Les biomarqueurs et les polymorphismes identifiés trouvent une utilisation dans des approches de diagnostic et de traitement, par exemple, dans certains modes de réalisation, on obtient des procédés et des kits permettant de détecter le carcinome bronchogène et les risques associés.

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