Methods and compositions for identifying morphogen analogs

Details Methods and compositions for identifying morphogen analogs Methods and compositions for identifying morphogen analogs

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 14/47 (2006.01) C07K 14/51 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2227769

Disclosed herein are methods and compositions for identifying morphogen analogs. Preferred methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. In certain embodiments, the methods involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.

L'invention concerne des procédés et des compositions permettant d'identifier des analogues de morphogènes. Selon des modes de réalisation préférés, les procédés consistent à utiliser des cellules d'essai comprenant un ADN définissant un élément d'activation de transcription sensible aux morphogènes, associé fonctionnellement à un gène reporter. Selon certains modes de réalisation, les méthodes utilisées comprennent un élément d'activation de transcription sensible à la protéine ostéogénique 1 (OP-1). Les substances qui activent l'élément d'activation de transcription sensible à l'OP-1 sont considérées dans le cadre de la présente invention comme pouvant être utiles pour reproduire in vivo les effets de morphogènes tels que l'OP-1.

Affiliated with

Also associated with

Rating

Methods and compositions for identifying morphogen analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for identifying morphogen analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for identifying morphogen analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1408465