Methods and compositions for identifying morphogenic protein...

Details Methods and compositions for identifying morphogenic protein... Methods and compositions for identifying morphogenic protein...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2394269

The present invention relates generally to methods and compositions for identifying morphogenic protein analogs. In one embodiment, this invention relates to an osteogenic protein reponsive transcription inhibitory element. This invention also relates to the identified morphogenic protein analogs which can mimic the biological effects of morphogenic proteins, particularly those relating to the BMP family such as osteogenic protein (OP-1), on the regulation of gene expression and tissue inductive capabilities.

La présente invention concerne généralement des méthodes et des compositions servant à identifier des analogues de la protéine morphogénique. Dans une forme de réalisation, l'invention concerne un élément inhibiteur de la transcription, sensible à la protéine ostéogénique. L'invention concerne en outre les analogues de la protéine morphogénique identifiées, qui peuvent mimer les effets biologiques des protéines morphogéniques (notamment celles se rapportant à la famille BMP, telles que les protéines ostéogéniques (OP-1)) sur la régulation de l'expression génétique et de l'activité inductive tissulaire.

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