A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/118 (2006.01)
Patent
CA 2609038
The present invention relates, in part, to methods and compositions for immunizing against infection by Chlamydia trachomatis. The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from C. trachomatis major outer membrane protein (MOMP) to a subject to be immunized. In some embodiments, the compositions comprise a chimeric immunogen comprising a receptor binding domain, a translocation domain, and a Chlamydia trachomatis antigen. Polynucleotides encoding the chimeric immunogens, expression vectors comprising the polynucleotides, and kits comprising the compositions are also provided.
L'invention se rapporte en partie à des méthodes et à des compositions permettant l'immunisation contres les infections par Chlamydia trachomatis. Ces méthodes et ces compositions font appel, en partie, à l'administration d'une composition immunogène contenant un ou plusieurs peptides dérivés de la protéine majeure de la membrane externe (MOMP) de C. trachomatis à un sujet devant être immunisé. Dans certains modes de réalisation, la composition contient un immunogène chimère comprenant un domaine de liaison de récepteur, un domaine de translocation, et un antigène de Chlamydia trachomatis. L'invention concerne également des polynucléotides codant pour les immunogènes chimères, des vecteurs d'expression comprenant ces polynucléotides, et des trousses contenant ces compositions.
Dean Deborah
Mrsny Randall J.
Children's Hospital & Research Center At Oakland
Osler Hoskin & Harcourt Llp
Trinity Biosystems Inc.
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