Methods and compositions for immunizing pigs against porcine...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/00 (2006.01)

Patent

CA 2710247

The present invention relates to the isolation and identification of two new strains of type 2B porcine circovirus. These two new strains of porcine circovirus may be used for the preparation of vaccine or immunogenic compositions for immunizing pigs against postweaning multisystemic wasting syndrome (PMWS). Accordingly, the invention provides methods for eliciting a protective immune response against a pathogenic porcine circovirus by administering to a pig an immunogenically effective amount of a type 2B porcine circovirus vaccine or immunogenic composition comprising at least one of the porcine circoviruses having a nucleic acid sequence as set forth in SEQ ID NOs: 1 or 2, or at least one protein from at least one of the two new type 2B strains of porcine circovirus as described herein. The invention further relates to protection of a pig from any one or more of the symptoms or sequelae associated with PMWS.

La présente invention concerne l'isolement et l'identification de deux nouvelles souches du circovirus porcin du type 2B. Ces deux nouvelles souches du circovirus porcin peuvent être utilisées pour préparer des compositions vaccinales ou immunogènes destinées à immuniser des porcs contre le syndrome de dépérissement en post-sevrage (PMWS). Par conséquent, l'invention concerne des procédés pour susciter une réponse immunitaire protectrice contre un circovirus porcin pathogène par administration à un porc d'une quantité immunologiquement efficace d'un vaccin contre le circovirus porcin du type 2B ou d'une composition immunogène comprenant au moins un des circovirus porcins ayant la séquence d'acides nucléiques décrite dans SEQ ID No.: 1 ou 2, ou au moins une protéine provenant d'au moins une des deux nouvelles souches du type 2B du circovirus porcin décrites dans la présente. L'invention concerne, en outre, la protection d'un porc contre un ou plusieurs des symptômes ou séquelles associés au syndrome PMWS.

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