Methods and compositions for immunoregulation

Details Methods and compositions for immunoregulation Methods and compositions for immunoregulation

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2403393

Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an agent that inhibits MD- 1 with or without an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of MD-1 or an agent that activates or stimulates MD-1.

Cette invention a trait à des techniques ainsi qu'à des compositions permettant de déclencher une immunosuppression. Ces techniques consistent à administrer une quantité efficace d'un agent inhibant MD-1 avec ou sans une protéine OX-2 ou un acide nucléique codant une protéine OX-2. Ces techniques s'avèrent des plus utiles s'agissant d'éviter un rejet de greffe, une perte foetale, une maladie auto-immune ainsi que des allergies. L'invention concerne également des techniques et des compositions permettant d'éviter une immunosuppression. Les techniques consistent à administrer une quantité efficace de MD-1 ou d'un agent qui active ou stimule MD-1.

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