Methods and compositions for impairing multiplication of hiv-1

Details Methods and compositions for impairing multiplication of hiv-1 Methods and compositions for impairing multiplication of hiv-1

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01)

Patent

CA 2597373

A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-I Tat protein displayed in multiple strains and subtypes of HIV-I. This "pan-epitope" antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-I infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-I based on a measurement of the amount of Tat protein in a biological sample.

Selon l'invention, un anticorps isolé unique ou un fragment de celui-ci se lie à de multiples séquences de variants dans un épitope de la protéine Tat de VIH-1 présente dans de multiples souches et sous-types de VIH-1. Cet anticorps de "pan-épitope" est utilisé dans des compositions thérapeutiques et prophylactiques ainsi que dans des traitements d'une infection au VIH-1, sans égard à la souche. Cet anticorps de pan-épitope est utile dans des dosages pour la détection des niveaux de VIH-1 fondée sur une mesure du taux de protéine Tat dans un échantillon biologique.

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