Methods and compositions for improving cognitive function

A - Human Necessities – 61 – K

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A61K 31/19 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2724386

The invention relates to methods and compositions for improving cognitive function by using a combination of valproic acid and analogs and derivatives thereof ("valproate") and an acetylcholinesterase inhibitor (AChEI). In particular, it re-lates to the use of a combination of a valproate and an AChEI in treating age-related cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-Associated Memory Impairment (AAMI) or Age-Related Cognitive Decline (ARCD).

L'invention concerne des procédés et des compositions permettant l'amélioration de la fonction cognitive en utilisant une combinaison d'acides valproïques et d'analogues et dérivés de ces acides ("valproate") et d'un inhibiteur de l'acétylcholinestérase (AchEI). En particulier, elle concerne l'utilisation d'une combinaison d'un valproate et d'un AChEI dans le traitement d'un trouble cognitif lié à l'âge, chez un sujet en ayant besoin ou présentant un risque de trouble cognitif, y compris, sans caractère limitatif, les sujets atteints ou présentant un risque de trouble cognitif léger (MCI), de déficience de la mémoire liée à l'âge (AAMI) ou de déclin cognitif lié à l'âge (ARCD).

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