C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/44 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2582194
Nucleic acid molecules modified to enhance recombinant protein expression, e.g., that of A.beta. peptide binding antibodies, and/or to reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing A.beta. peptide binding antibodies devoid of mis-spliced and/or intron read-through by- products by expression of such nucleic acid molecules under cell culture conditions suitable for recombinant A.beta. peptide binding antibody expression.
L'invention porte sur des molécules d'acide nucléique modifiées afin d'améliorer l'expression de protéines recombinantes, par exemple celle des anticorps de liaison du peptide Aß, et/ou afin de réduire ou d'éliminer des sous-produits mal épissés et/ou à transcription intronique. Cette invention concerne des procédés des fabrication d'anticorps de liaison du peptide Aß dépourvus de sous-produits mal épissés et/ou à transcription intronique par expression de ces molécules d'acide nucléique dans des conditions de culture cellulaire qui conviennent à l'expression de l'anticorps de liaison du peptide Aß.
Rouse Jason
Sinacore Martin S.
Gowling Lafleur Henderson Llp
Janssen Alzheimer Immunotherapy
Neuralab Limited
Wyeth
Wyeth Llc
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