A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 7/16 (1995.01)
Patent
CA 2214829
A kit is provided for in vivo detection of cancerous and precancerous tissue. The kit includes two solutions. The first solution is a biological stain composition for rinsing the oral cavity, and comprises both a non-toxic dye other than toluidine blue O and methylene blue, the non-toxic dye having the structure (see formula I) and ionic derivatives thereof, wherein R1 is H, a lower alkyl group or N(R3)2, R2 is N, S or O, and R3 is H or a lower alkyl group, and a pharmaceutically-acceptable oxidizing agent for leuco forms of the dye. The second solution is a rinse composition for removing unretained stain composition. The use which is taught for such kit includes the step of sequentially rinsing the oral cavity with that stain composition which is selectively retained by cancerous and precancerous oral tissues. The dye in the stain composition consists essentially of a dye which is either Azure B, Azure C or Brilliant Cresyl Blue. The oral cavity is then rinsed with a rinse composition for removing unretained stain composition.
Procédé permettant de détecter in-vivo les lésions précancéreuses et les carcinomes de la cavité buccale, ce procédé consistant à appliquer sur les tissus de la cavité buccale un colorant non toxique qui n'est pas le bleu de toluidine O, sélectionné parmi les composés de formule (I) et des dérivés ioniques de ce dernier, dans laquelle R<1> représente H ou un groupe alkyle inférieur ou N(R<3>)2, R<2> représente N, S ou O et R<3> représente H ou un groupe alkyle inférieur.
Pomerantz Edwin
Borden Ladner Gervais Llp
Zila Biotechnology Inc.
Zila Pharmaceuticals Inc.
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