C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/43 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2692453
Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins. Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
L'invention concerne des procédés et des compositions pour inactiver un gène FUT8 au moyen de protéines de fusion qui renferme une protéine à doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. Des polynucléotides codant les protéines de fusion sont également fournis, ainsi que des cellules comprenant les polynucléotides et les protéines de fusion.
Collingwood Trevor
Cost Gregory J.
Kirby Eades Gale Baker
Sangamo Bioscience Inc.
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