Methods and compositions for inactivating glutamine...

Details Methods and compositions for inactivating glutamine... Methods and compositions for inactivating glutamine...

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C12N 5/07 (2010.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/00 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2741119

Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

L'invention porte sur des procédés et des compositions pour inactiver un gène de la glutamine synthétase (GS), à l'aide de protéines de fusion comprenant une protéine en doigt de zinc et un domaine de clivage ou un demi-domaine de clivage. L'invention porte également sur des polynucléotides codant pour lesdites protéines de fusion, ainsi que sur des cellules comprenant lesdits polynucléotides et lesdites protéines de fusion.

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