Methods and compositions for inactivation of dihydrofolate...

Details Methods and compositions for inactivation of dihydrofolate... Methods and compositions for inactivation of dihydrofolate...

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C07K 14/00 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2650414

Disclosed herein are methods and compositions for inactivating dihydrofolate reductase genes, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Il est décrit ici des procédés et compositions pour inactiver les gènes de dihydrofolate réductase, en utilisant des protéines hybrides comprenant une protéine à doigts de zinc et un domaine de clivage ou un demi-domaine de clivage. Des polynucléotides codant lesdites protéines hybrides sont également prévus, ainsi que des cellules comprenant lesdits polynucléotides et protéines hybrides.

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