Methods and compositions for increasing antibody production

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2499300

The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.

L'invention concerne des méthodes et des compositions destinées à assurer une expression et une production améliorées d'anticorps recombinants dans des systèmes d'expression de cellules hôtes. L'invention concerne en particulier l'expression et la production procaryotes d'anticorps présentant des résidus de cystéine charnière modifiée. L'invention concerne en outre des compositions, des trousses et des articles manufacturés servant à mettre en oeuvre les méthodes de l'invention.

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