A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2532547
The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.
L'invention concerne généralement des méthodes et des compositions pour augmenter l'efficacité d'anticorps thérapeutiques. Leur efficacité est augmentée par l'amélioration du mécanisme de la cytotoxicité cellulaire dépendant d'anticorps (ADCC). Plus spécifiquement, l'invention concerne l'utilisation d'un anticorps thérapeutique en combinaison avec des composés qui bloquent un récepteur inhibiteur ou stimulent un récepteur activant d'une cellule NK afin d'améliorer l'efficacité du traitement de patients humains par des anticorps thérapeutiques.
Romagne Francois
Velardi Andrea
Innate Pharma
Robic
Universita Degli Studi Di Perugia
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