A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 45/08 (2006.01) C12N 15/11 (2006.01) C12N 15/83 (2006.01)
Patent
CA 2271826
The present invention involves methods and compositions for increasing the susceptibility of target cells to viral infection. Specifically, it is proposed that increasing intracellular permeability in epithelial tissue increases the percentage of input virus that will infect that target tissue. Specific examples show that receptors for retrovirus are preferentially accessible on the basolateral surface of airway epithelia, and permeabilizing such tissues results in greater infection with retrovirus. This has important implications in gene therapy, for example, to treat cystic fibrosis with the CFTR gene.
Bodner Mordecai
Davidson Beverly
Herrmann Steven M.
Jolly Douglas J.
Mccray Paul B. Jr.
Bereskin & Parr
Chiron Corporation
The University Of Iowa Research Foundation
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