Methods and compositions for increasing the sensitivity of a...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/48 (2006.01) A61K 31/70 (2006.01) A61K 33/24 (2006.01) A61N 5/10 (2006.01) C12N 9/12 (2006.01) G01N 33/573 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2136094

The invention provides a method of increasing the sensitivity of a cell to a DNA damaging agent comprising increasing the amount of an NM23 in the cell. The method is especially useful for increasing the sensitivity of tumor cells to chemotherapy and radiation.

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