Methods and compositions for inducing oral tolerance in mammals

Details Methods and compositions for inducing oral tolerance in mammals Methods and compositions for inducing oral tolerance in mammals

A - Human Necessities

61

K

A61K 47/16 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61K 47/20 (2006.01)

Patent

CA 2243643

The present invention relates to methods and pharmaceutical formulations for orally delivering an antigen to induce tolerance. The antigen is combined with derivatized amino acids or salts thereof. The induction of oral tolerance may be applied clinically for the prevention or treatment of auto-immune diseases and clinical allergic hypersensitivities, and for the prevention of allograft rejection. The figure illustrates examples of the derivatized amino acids.

L'invention concerne des procédés et des formulations pharmaceutiques pour l'administration orale d'un antigène, visant à induire une tolérance. L'antigène est combiné avec des dérivés d'acides aminés ou de leurs sels. L'induction d'une tolérance orale a des applications cliniques, pour la prévention ou le traitement de maladies auto-immunes et d'hypersensibilités allergiques cliniques, ainsi que pour la prévention de rejets d'allogreffes. La figure donne des exemples de dérivés d'acides aminés.

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