A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C07K 14/65 (2006.01)
Patent
CA 2308124
The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters inlcude H19 regulatory sequences, the IGF-I promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
Cette invention concerne l'expression spécifique de séquences hétérologues, notamment de gènes codant des produits cytotoxiques, dans des cellules cancéreuses et sous le contrôle de séquences de transcription régulatrices. Les promoteurs préférés comprennent particulièrement les séquences régulatrices H19, le promoteur d'IGF-1 ainsi que les promoteurs P3 et P4 d'IGF-2. Cette invention concerne également des produits de synthèse d'expression, ainsi que des procédés permettant de les administrer. Les compositions et les procédés faisant l'objet de cette invention sont utiles dans le traitement du cancer.
Ayesh Suhail
Hochberg Abraham
Osler Hoskin & Harcourt Llp
Yissum Research Development Company Of The Hebrew University Of
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