A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/02 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2410458
Methods and compositions for treating or preventing immunoglobulin-mediated reperfusion or ischemic injury, in a subject, are provided. Methods for identifying inhibitors of an interaction between a pathogenic immunoglobulin and an ischemic antigen or a component of the complement pathway are provided. Pathogenic immunoglobulins and mutated forms thereof are also disclosed.
L'invention porte sur des procédés et sur des compositions visant à traiter ou prévenir, chez un sujet, les lésions ischémiques ou lésions au retour de la perfusion induites par l'immunoglobuline. L'invention porte également sur des procédés d'identification d'inhibiteurs d'une interaction entre une immunoglobuline pathogène et un antigène ischémique ou un composant de processus complémentaire. Des immunoglobulines pathogènes et leurs formes mutées sont également décrites.
Carroll Michael C.
Hechtman Herbert B.
Moore Francis D. Jr.
Brigham And Women's Hospital
Immune Disease Institute Inc.
President And Fellows Of Harvard College
Smart & Biggar
The Center For Blood Research Inc.
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