A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 9/00 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2421503
Methods for inhibiting angiogenesis in endothelial cells and selectively inducing apoptosis in endothelial cells via compounds which binds annexin II are provided. These compounds and methods for using these compounds are useful in the treatment of diseases or disorders characterized by unwanted angiogenesis. Also provided are pharmaceutical compositions containing a compound which binds annexin II and a pharmaceutically acceptable vehicle and methods for identifying such compounds.
La présente invention concerne des méthodes d'inhibition de l'angiogenèse et d'induction sélective de l'apoptose dans les cellules endothéliales, faisant intervenir des composés qui se lient à l'annexine II. Ces composés et leurs méthodes d'utilisation sont utilisés dans le traitement de maladies et de troubles caractérisés par l'angiogenèse non souhaitée. Par ailleurs, l'invention concerne des compositions pharmaceutiques contenant un composant qui se lie à l'annexine II et un support acceptable d'un point de vue pharmaceutique, ainsi que des méthodes d'identification de ces composés.
Sharma Mahesh C.
Tuszynski George P.
Borden Ladner Gervais Llp
Philadelphia Health And Education Corporation
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