Methods and compositions for inhibiting angiogenesis

A - Human Necessities – 61 – K

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Details

A61K 38/57 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C07K 14/81 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2298018

The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.

L'invention concerne un procédé pour inhiber l'angiogenèse dans un tissu en fournissant aux cellules associées à ce tissu une protéine SLED (antiangiogenèse) exogène, dont la présence inhibe l'angiogenèse à l'intérieur du tissu, en partie par interférence avec la capacité de l'endothélium vasculaire à se développer dans le tissu. L'invention concerne également un procédé pour déterminer le degré de gravité d'une tumeur en effectuant une analyse pour déceler la présence de protéine SLED dans la tumeur. Pour faciliter la mise en oeuvre des procédés décrits, l'invention concerne aussi des compositions pharmaceutiques renfermant des sources de protéine SLED.

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