Methods and compositions for inhibiting cd14 mediated cell...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2163976

This invention provides hybridoma cell lines producing monoclonal antibodies which inhibit CD14 mediated cell activation. Monoclonal antibodies produced by these cell lines also are provided. The antibodies are useful for the detection of the presence of cell surface and soluble CD14 in a sample. Chimeric and CDR grafted antibodies generated from the above monoclonal antibodies are further provided. Pharmaceutical compositions containing the above biological compositions are provided. These are useful to treat and prevent disorders associated with CD14 mediated cell activation, such as spesis.

L'invention concerne des lignées cellulaires d'hybridomes produisant des anticorps monoclonaux inhibant l'activation de cellules induites par C14. Les anticorps monoclonaux produits par ces lignées cellulaires sont également décrits. Lesdits anticorps sont utilisés pour détecter la présence de CD14 soluble et à la surface des cellules dans un échantillon. L'invention porte également sur des anticorps chimères et greffés aux régions déterminantes complémentaires générés à partir des anticorps monoclonaux mentionnés.ci-dessus. Des compositions pharmaceutiques contenant les compositions biologiques sus-mentionnées sont également décrites. Elles sont utiles pour traiter et prévenir les troubles associés à l'activation des cellules induites par CD14 tels que la septicémie.

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