C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/535 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/27 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2622504
The present invention provides compositions and methods that enhance cell survival. Such compositions feature chimeric polypeptides that include at least a GM-CSF receptor ligand and an anti-apoptotic moiety (e.g., a Bcl-2 protein family member). In one embodiment, the chimeric polypeptide is a GM-CSF-Bcl-xL chimeric polypeptide. The invention further includes methods of using chimeric polypeptides to enhance cell survival or inhibit cell death in a cell at risk of cell death.
La présente invention concerne des compositions et des procédés qui renforcent la survie des cellules. De telles compositions comprennent des polypeptides chimériques qui comprennent au moins un ligand du récepteur GM-CSF et un fragment anti-apoptotique (par exemple, un élément de la famille de la protéine Bcl-2). Dans un mode de réalisation, le polypeptide chimérique est un polypeptide chimérique GM-CSF-Bcl-xL. L'invention comprend en outre des procédés d'utilisation de polypeptides chimériques destinés à renforcer la survie des cellules ou à inhiber la mort des cellules dans une cellule susceptible de mourir.
Antignani Antonella
Youle Richard J.
Antignani Antonella
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Department Of He Alth And Human Services Government Of The Usa As Represented By The Secretary
Youle Richard J.
LandOfFree
Methods and compositions for inhibiting cell death or... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for inhibiting cell death or..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for inhibiting cell death or... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1969016