Methods and compositions for inhibiting endothelial cell and...

Details Methods and compositions for inhibiting endothelial cell and... Methods and compositions for inhibiting endothelial cell and...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 38/36 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 14/705 (2006.01) C07K 14/75 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137813

The present invention contemplates therapeutic compositions containing a fibrinogen homolog capable of binding to endo- thelial cells in an RGD-independent manner that inhibits fibrinogen binding to endothelial cells. Also described are therapeutic compositions containing an ICAM-1 homolog capable of binding to fibrinogen in an RGD-independent manner that inhibits fib- rinogen binding to endothelial cells. Methods of inhibating endothelial cell and fibrinogen mediated inflammation within a pa- tient by administering a homolog of this invention are also contemplated.

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