Methods and compositions for inhibiting hiv infection

Details Methods and compositions for inhibiting hiv infection Methods and compositions for inhibiting hiv infection

G - Physics

01

N

G01N 33/50 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2629822

This invention provides novel HIV-interacting host factors. The invention also provides methods of using the HIV-interacting host factors to screen for compounds that inhibit HIV infection. The methods comprise first screening test compounds for modulators of an HIV-interacting host factor disclosed herein, and then further screening the identified modulating compounds for ability to inhibit HIV infection. The invention further provides methods and pharmaceutical compositions for treating diseases and conditions associated with HIV infection.

La présente invention concerne de nouveaux facteurs hôtes interagissant avec le VIH. L~invention concerne également des procédés d~utilisation des facteurs hôtes interagissant avec le VIH pour le criblage de composés inhibant l'infection par le VIH. Ces procédés consistent tout d~abord à cribler des composés test afin d~identifier des modulateurs d~un facteur hôte interagissant avec le VIH selon la présente invention, puis à cribler des composés modulateurs identifiés afin de distinguer leur capacité à inhiber l'infection par le VIH. L~invention concerne également des procédés et des compositions pharmaceutiques pour le traitement de maladies et d~états associés à l~infection par le VIH.

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