Methods and compositions for inhibiting integrins using...

Details Methods and compositions for inhibiting integrins using... Methods and compositions for inhibiting integrins using...

A - Human Necessities

61

K

A61K 33/04 (2006.01) A61K 31/33 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2705944

Compositions and methods for inhibiting integrin and treating integrin-related conditions, utilizing tellurium-containing compounds, are disclosed. The tellurium-containing compounds comprise at least one tellurium dioxo moiety and may have any one of Formulae I to IV as defined in the specification. Further disclosed are compositions and methods for treating a neoplastic condition characterized by a resistance to an anti-neoplastic agent and by a high level of expression of an integrin by neoplastic cells.

L'invention porte sur des compositions et des procédés pour inhiber l'intégrine et traiter des états se rapportant à l'intégrine, à l'aide de composés contenant du tellure. Les composés contenant du tellure comprennent au moins une fraction dioxo tellure et peuvent avoir l'une des Formules I à IV telles que définies dans la description. L'invention porte en outre sur des compositions et des procédés pour traiter un état néoplasique caractérisé par une résistance à un agent antinéoplasique et par un niveau élevé d'expression d'une intégrine par des cellules néoplasiques.

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