C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2348157
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
L'invention concerne des méthodes et des compositions permettant d'inhiber la croissance de cellules néoplasiques. Cette invention concerne plus spécialement des compositions antinéoplasiques et des méthodes de traitement des tumeurs. Elle concerne encore des méthodes de criblage permettant d'identifier les inhibiteurs de croissance, par exemple des composés antinéoplasiques. La présente invention a en outre trait à des nouveaux polypeptides et à des molécules d'acide nucléiques codant pour ces polypeptides. L'invention porte encore sur: des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules de polypeptides chimériques où les polypeptides obtenus selon l'invention sont fusionnés à des séquences de polypeptides hétérologues, des anticorps qui se lient aux polypeptides obtenus selon l'invention, et des méthodes de préparation de ces polypeptides.
Chen Jian
Goddard Audrey
Gurney Austin L.
Hillan Kenneth
Napier Mary
Dennison Associates
Genentech Inc.
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