C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2373915
The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
La présente invention concerne des procédés et des compositions visant à inhiber la prolifération des cellules cancéreuses. Cette invention concerne notamment des compositions antitumorales et des procédés de traitement de ces tumeurs. L'invention concerne également des procédés de recherche automatique visant à identifier des composés antitumoraux inhibant la prolifération. La présente invention concerne en outre de nouveaux polypeptides et des molécules d'acide nucléique codant ces polypeptides; des vecteurs et des cellules hôtes comprenant ces séquences d'acide nucléique; des molécules polypeptidiques chimères comprenant les polypeptides de cette invention fusionnés aux séquences polypeptidiques hétérologues; des anticorps se liant à ces polypeptides et des procédés de production de ces polypeptides.
Baker Kevin P.
Goddard Audrey
Gurney Austin L.
Hebert Caroline
Henzel William
Dennison Associates
Genentech Inc.
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