A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/00 (2006.01) A61K 39/38 (2006.01) C07K 16/22 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2450590
Methods and compositions for inhibiting, preventing, or reducing tumor cell growth in patients resistant to the antineoplastic effects of antiestrogen therapy are provided. Increased levels of the PCDFG (GP88) growth factor are indicative of tumorigenicity andresistance to the pharmacological effects of antiestrogen therapy.The methods and compositions of the invention are useful for treating or preventing the re-ocurrence of cancer in patients that are resistant to antiestrogen therapy.
Cette invention porte sur des méthodes et des compositions d'inhibition, de prévention ou de réduction de croissance cellulaire tumorale chez des patients résistants aux effets anti-néoplasiques d'un traitement anti-oestrogène. Des niveaux accrus du facteur de croissance PCDGF (GP88) sont indicateurs d'une action cancérigène et d'une résistance aux effets pharmacologiques d'un traitement anti-oestrogène. Les méthodes et compositions de la présente invention servent au traitement ou à la prévention de la réapparition du cancer chez des patients qui résistent à un traitement anti-oestrogène.
A&g Pharmaceuticals Inc.
Mccarthy Tetrault Llp
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