C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01)
Patent
CA 2199419
The present invention provides methods and compositions for inhibiting the production of replication competent virus. The invention comprises nucleic acid cassettes encoding a non-biologically active inhibitory molecule which are incorporated into packaging cells and recombinant vector constructs. Upon recombination between various vector construct contained within the producer cell, a biologically active molecule is produced which kills the cell, thereby inhibiting production of replication competent virus.
L'invention concerne des procédés et des compositions destinés à inhiber la production de virus aptes à la réplication. Elle porte encore sur des cassettes d'acide nucléique codant une molécule inhibitrice non biologiquement active qui sont incorporées dans des cellules d'encapsidation et des produits d'assemblage de vecteurs de recombinaison. Lors de la recombinaison entre divers produits d'assemblage vectoriels contenus dans la cellule productrice, une molécule biologiquement active qui tue la cellule est produite, ce qui inhibe la production de virus aptes à la réplication.
Jolly Douglas J.
Klump Wolfgang
Borden Ladner Gervais Llp
Chiron Corporation
Chiron Viagene Inc.
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