Methods and compositions for inhibiting uridine secretion

Details Methods and compositions for inhibiting uridine secretion Methods and compositions for inhibiting uridine secretion

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/24 (2006.01) A61K 31/495 (2006.01) A61K 31/515 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) C07C 219/14 (2006.01) C07D 295/088 (2006.01)

Patent

CA 2167688

Methods and pharmaceutical compositions effective to increase intracellular and plasma uridine concentrations are disclosed. Certain compositions and methods of using such compositions have been found to be effective to inhibit uridine secretion in a subject, thus increasing uridine concentration. Treatments that increase uridine concentrations are useful to combat many treatments and can also be effective in protecting or rescuing uninfected and normal cells that are subject to toxic side effects induced by the administration of certain chemotherapeutic compounds.

L'inventon concerne des procédés et des compositions pharmaceutiques efficaces pour accroître les concentrations intracellulaires et plasmatiques d'uridine. Certaines compositions et certains procédés d'utilisation de ces compositions se sont révélées efficaces pour inhiber la secrétion d'uridine chez un individu, accroissant ainsi la concentration de l'uridine. Les traitements qui accroissent les concentrations d'uridine sont utiles pour combattre les effets secondaires de nombreux traitements et peuvent aussi se révéler efficaces pour protéger et secourir les cellules non infectées et normales exposées aux effets secondaires toxiques de l'administration de certains composés chimiothérapeutiques.

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