Methods and compositions for inhibition of angiogenesis

Details Methods and compositions for inhibition of angiogenesis Methods and compositions for inhibition of angiogenesis

A - Human Necessities

61

K

A61K 31/454 (2006.01)

Patent

CA 2512926

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis. Importantly, these compounds can be administered orally.

La présente invention porte sur un groupe de composés qui inhibent efficacement l'angiogenèse. De façon plus précise, il a été établi que la thalidomide et divers composés apparentés comme les précurseurs de la thalidomide, des analogues, des métabolites et des produits d'hydrolyse inhibent l'angiogenèse. Plus important encore, ces composés peuvent être administrés par voie orale.

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