A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/454 (2006.01) A61K 31/192 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2514681
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, antiinflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, thee compounds can be administered orally.
La présente invention porte sur un groupe de composés qui inhibent efficacement l'angiogenèse. De façon plus précise, il a été établi que la thalidomide et divers composés apparentés comme les précurseurs de la thalidomide, des analogues, des métabolites et des produits d'hydrolyse inhibent l'angiogenèse et permettent de traiter des affections résultant de l'angiogenèse. En outre, des médicaments anti-inflammatoires, comme les stéroïdes et les AINS, peuvent inhiber des maladies dépendantes de l'angiogenèse seuls ou en association avec la thalidomide et des composés apparentés. Plus important encore, ces composés peuvent être administrés par voie orale.
Smart & Biggar
The Children's Medical Center Corporation
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