Methods and compositions for inhibition of angiogenesis

Details Methods and compositions for inhibition of angiogenesis Methods and compositions for inhibition of angiogenesis

A - Human Necessities

61

K

A61K 31/60 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/33 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/56 (2006.01) A61K 31/621 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2270887

The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, antiinflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.

Cette invention a trait à un groupe de composés inhibant de manière efficace l'angiogenèse. Plus précisément, il s'est avéré que la thalidomide et divers composés apparentés tels que des précurseurs, des analogues, des métabolites et des produits d'hydrolyse de la thalidomide étaient à même d'inhiber une angiogenèse et de traiter des états pathologiques provoqués par celle-ci. En outre, des médicaments anti-inflammatoires, notamment des stéroïdes et des anti-inflammatoires non stéroïdiens peuvent faire obstacle à des maladies occasionnées par une angiogenèse, seuls ou associés à la thalidomide et à des composés apparentés. Fait important, ces composés peuvent être administrés par voie orale.

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