C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/16 (2006.01) A61K 38/16 (2006.01) C07K 14/005 (2006.01) C07K 14/02 (2006.01) C07K 14/05 (2006.01) C07K 14/11 (2006.01) C07K 14/115 (2006.01) C07K 14/12 (2006.01) C07K 14/125 (2006.01) C07K 14/13 (2006.01) C07K 14/135 (2006.01) C07K 14/15 (2006.01) C07K 14/155 (2006.01) C07K 14/21 (2006.01) C07K 14/22 (2006.01) C07K 14/285 (2006.01) C07K 14/31 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2208420
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp4l protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
La présente invention concerne des peptides qui présentent une activité importante contre les rétrovirus. Les peptides de l'invention comprennent le peptide DP178 (SEQ ID:1) correspondant aux acides aminés 638 à 673 de la protéine VIH-1LAI gp41 et des fragments, analogues et homologues de DP178. L'invention concerne en outre l'utilisation de ces peptides comme inhibiteurs de la transmission à des cellules non infectées de rétrovirus humains ou non humains, en particulier du VIH.
Barney Shawn O'lin
Bolognesi Dani P.
Lambert Dennis M.
Langlois Alphonse J.
Matthews Thomas J.
Duke University
Osler Hoskin & Harcourt Llp
Trimeris Inc.
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