Methods and compositions for liposomal formulation of...

C - Chemistry – Metallurgy – 07 – J

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C07J 9/00 (2006.01) A01N 45/00 (2006.01) A61K 9/127 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61K 47/48 (2006.01) C07J 7/00 (2006.01) A61K 39/00 (2006.01) C07K 17/02 (2006.01)

Patent

CA 2754896

The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine ("DMPC"); either dimyristoylphosphatidylglycerol ("DMPG") or dimyristoyltrimethylammonium propane ("DMTAP") or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).

La présente invention porte sur des compositions de vaccin liposomal, sur leurs procédés de fabrication et sur leurs procédés d'utilisation pour stimuler une réponse immunitaire chez un animal. Ces compositions comprennent de la dimyristoylphosphatidylcholine (« DMPC »); soit du dimyristoylphosphatidylglycérol (« DMPG ») soit du propane de dimyristoyltriméthylammonium (« DMTAP ») ou à la fois du DMPC et du DMTAP; et au moins un dérivé de stérol fournissant un ancrage covalent pour un ou plusieurs polypeptides ou glucides immunogènes.

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