C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2490713
Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described.
L'invention concerne des proc~d~s et des compositions de manipulation de navigation dirig~e de structures tubulaires de localisation physiologique. L'invention concerne ~galement un nouveau r~cepteur cellulaire, le r~cepteur <=roundabout-4>= (Robo-4). Ce r~cepteur Robo-4 pr~sente une similarit~ s~quentielle et structurale avec des membres de la famille de r~cepteurs <=roundabout>=. Le r~cepteur Robo-4 se lie ~galement au ligand Slit, un r~cepteur connu des r~cepteurs <=roundabout>=. L'invention concerne en outre des polynucl~otides et polypeptides du r~cepteur Robo-4.
Li Dean Y.
Park Kye Won
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Utah Research Foundation
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