Methods and compositions for modification of the human...

Details Methods and compositions for modification of the human... Methods and compositions for modification of the human...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C07K 14/72 (2006.01) C12N 9/22 (2006.01) C12N 15/00 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2667414

Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

L'invention concerne des procédés et des compositions pour l'inactivation du gène du récepteur des glucocorticoïdes humain (GR). Ces procédés et ces compositions sont utiles par exemple dans des applications thérapeutiques nécessitant une conservation de la fonction immunitaire lors d'un traitement aux glucocorticoïdes

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