Methods and compositions for modulating a steroid receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/72 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 15/06 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2553609

Methods, compositions, and uses are provided for modulating a steroid receptor or process mediated by a steroid receptor in a cell by administering a polypyridimine tract binding protein-associated splicing factor (PSF) polypeptide, a polynucleotide encoding the polypeptide, an isolated complex of a PSF polypeptide and a steroid receptor, and/or an agonist or antagonist thereof, in an effective amount to modulate the steroid receptor or process. Particular aspects of the invention relate to detection, monitoring, modulation, treatment and/or prevention of the onset of labor.

La présente invention concerne des procédés, des compositions, et leurs utilisations, pour moduler un récepteur de stéroïde ou un processus lié à un récepteur de stéroïde dans une cellule, par administration d'un polypeptide facteur d'épissage de protéine de liaison de canal de polypyridimine (PSF), un polynucléotide codant pour ce polypeptide, un complexe isolé d'un polypeptide PSF et d'un récepteur de stéroïde, et/ou un agoniste ou antagoniste de celui-ci, en une quantité efficace pour moduler le récepteur de stéroïde ou le processus. Des aspects particuliers de l'invention ont trait à la détection, la surveillance, la modulation, le traitement et/ou la prévention de l'entrée en phase de travail.

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