Methods and compositions for modulating a t cell response

Details Methods and compositions for modulating a t cell response Methods and compositions for modulating a t cell response

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 39/00 (2006.01) A61K 39/008 (2006.01) A61K 39/35 (2006.01) C07K 7/06 (2006.01) C07K 14/44 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2198940

T cell modulatory peptides, methods for identifying such peptides and methods of use therefor are provided in the present invention. In one embodiment T cell modulatory peptides for a specific antigen are identified which stimulate interferon-gamma secreting Th1 cells and which have a high MHC binding affinity; these modulatory peptides can be administered to a subject to modulate, for example, allergic disorders. In another embodiment T-cell modulatory peptides for a specific antigen are identified which stimulate IL-4 secreting Th2 cells and which have a low MHC binding affinity; these modulatory peptides can be administered to a subject to modulate, for example, autoimmune disorders.

Cette invention concerne des peptides modulant les cellules T, des procédés d'identification de ces peptides ainsi que des procédés d'utilisation associés. Dans une forme de l'invention, on identifie des peptides modulant les cellules T destinés à un antigène spécifique qui stimulent les cellules Th1 sécrétant des interféron-gamma et qui présentent une forte affinité de liaison pour le complexe majeur d'histocompatibilité (CMH); on peut administrer ces peptides modulateurs à un patient pour moduler les pathologies allergiques par exemple. Dans une autre forme de l'invention on identifie des peptides modulant les cellules T destinés à un antigène spécifique qui stimulent les cellules Th2 sécrétant de l'IL-4 et qui présentent une faible affinité de liaison pour le CMH; on peut administrer ces peptides modulateurs à un patient pour moduler les pathologies auto-immunes par exemple.

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