C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/71 (2006.01)
Patent
CA 2723449
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I(ALKI) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALKI may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALKI and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction
Dans certains aspects, la présente invention concerne lidée selon laquelle un polypeptide comprenant une partie de liaison au ligand du domaine extra-cellulaire du polypeptide ALKl (pour activin-like kinase I)peut être utilisé pour inhiber langiogenèse in vivo, particulièrement chez les mammifères souffrant de pathologies liées à langiogenèse. De plus, linvention démontre que les inhibiteurs dALKl peuvent être utilisés pour augmenter la couverture par les péricytes dans les tissus vascularisés, notamment les tumeurs et la rétine. Linvention identifie également les ligands à ALKl et démontre que lesdits ligands ont une activité pro-angiogène, et décrit des anticorps qui inhibent linteraction récepteur/ligand.
Grinberg Asya
Knopf John
Kumar Ravindra
Pearsall Robert Scott
Pietras Kristian
Acceleron Pharma Inc.
Ludwig Institute For Cancer Research Ltd.
Smart & Biggar
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