Methods and compositions for modulating apoptosis

Details Methods and compositions for modulating apoptosis Methods and compositions for modulating apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2462638

Methods and compositions for modulating apoptosis by acting on the c-Jun-N- terminal kinase (JNK) pathway. Assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway. A member of the Gadd45 protein family that inhibits JNK signaling is a target. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.

L'invention concerne des procédés et des compositions permettant de moduler une apoptose par action sur la voie de la protéine c-Jun-N-terminale kinase (JNK). L'invention concerne également des tests destinés à l'isolation d'agents pouvant moduler une apoptose, notamment des modulateurs de la voie JNK. L'obtention d'un élément de la famille de protéine Gadd45 qui inhibe la signalisation de la voie JNK est visée. L'invention concerne en outre des procédés et des compositions destinés à la préparation et à l'utilisation de nouvelles compositions thérapeutiques permettant de moduler des maladies et des états associés à une apoptose élevée ou diminuée.

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