C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) G01N 33/53 (2006.01) G06F 17/50 (2006.01)
Patent
CA 2700925
The present invention is based, at least in part, on the identification of a novel active site on BCL-2 family polypeptide such as BAX, which when bound by a compound, modifies the activity of the BCL-2 family polypeptide.
La présente invention est basée, au moins en partie, sur l'identification d'un nouveau site actif sur un polypeptide de la famille BCL-2 tel que BAX, lequel lorsqu'il est lié à un composé, modifie l'activité du polypeptide de la famille BCL-2.
Bird Gregory H.
Gavathiotis Evripidis
Suzuki Motoshi
Tjandra Nico
Walensky Loren D.
Dana Farber Cancer Institute
National Institute Of Health
Ridout & Maybee Llp
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