Methods and compositions for modulating bmp-10 activity

Details Methods and compositions for modulating bmp-10 activity Methods and compositions for modulating bmp-10 activity

C - Chemistry, Metallurgy

07

K

C07K 14/51 (2006.01)

Patent

CA 2685306

Methods and compositions for modulating cardiac, renal and vascular cell function and homeostasis using agonists and antagonists of BMP-IO are disclosed. In particular, methods for treating, preventing and/or diagnosing BMP-10-associated vascular, renal, fibrotic and cardiac conditions and/or disorders are disclosed. Screening methods for evaluating BMP-IO modulators, e.g., agonists and antagonists, are also disclosed.

L'invention concerne des méthodes et des compositions destinées à moduler la fonction de cellules cardiaques, rénales et vasculaires et l'homéostase, au moyen d'agonistes et d'antagonistes de BMP-10. Elle concerne en particulier des méthodes de traitement, de prévention et/ou de diagnostic d'affections vasculaires, rénales, fibreuses et cardiaques et/ou de troubles associés à BMP-10. Elle concerne en outre des méthodes de criblage destinées à évaluer des modulateurs de BMP-10, tels que, par exemple, des agonistes et des antagonistes.

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