Methods and compositions for modulating cox

Details Methods and compositions for modulating cox Methods and compositions for modulating cox

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01N 61/00 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2613012

The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke.

L'invention concerne un essai pour déterminer si un agent d'essai est un modulateur de la COX. En règle générale, l'essai consiste à déterminer si un agent d'essai module la liaison d'un polypeptide contenant du PDZ et d'un polypeptide contenant de la COX PL. Le polypeptide contenant du PDZ peut comporter le domaine PDZ du domaine PDZ de MAGI1, TIP-1, MAST2, PSD95 ou SHANK. Ces essais doivent être réalisés dans un environnement acellulaire ou cellulaire, notamment avec une cellule neuronale. L'invention peut être appliquée dans une variété de domaines thérapeutiques, y compris pour identifier des agents servant dans le traitement du cancer, de la douleur, de l'inflammation et de troubles neuronaux dus à une attaque, par ex., un AVC.

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