A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2437727
The invention provides novel methods and compositions for modulating gluconeogenesis through modulation of PGC-1 activity or expression. Also provided are methods for identifying compounds that modulate gluconeogenesis through modulation of PGC-1 activity or expression, as well as methods for identifying compounds that modulate the interaction of PGC-1 with PGC-1 target molecules. Further provided are methods for treating disorders characterized by aberrant gluconeogenesis.
L'invention concerne de nouveaux procédés et de nouvelles compositions pour moduler la gluconéogenèse par modulation de l'activité ou de l'expression de PGC-1. L'invention concerne également des procédés d'identification de composés qui modulent la gluconéogenèse par modulation de l'activité ou de l'expression de PGC-1, ainsi que des procédés d'identification de composés qui modulent l'interaction de PGC-1 et de molécules cibles de PGC-1. Sont également décrits des procédés de traitement de troubles caractérisés par une gluconéogenèse aberrante.
Spiegelman Bruce
Yoon Clifford Hyunsuk
Borden Ladner Gervais Llp
Dana-Farber Cancer Institute Inc.
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