G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2548254
The present invention provides screening methods for identifying agents that modulate the activity of mitochondrial aldehyde dehydrogenase-2 (AIdDH2), as well as agents identified by the screening methods. The present invention further provides methods of reducing ischemic tissue damage or free-radical induced damage in an organ, the methods generally involving contacting the organ with an agent that increases AldDH2 levels and/or activity. The present invention further provides methods of treating solid tumors, the methods generally involving administering an agent that decreases A1dDH2 levels and/or activity.
La présente invention concerne des méthodes de criblage destinées à identifier des agents modulant l'activité de l'aldéhyde déshydrogénase-2 mitochondrial (AIdDH2), ainsi que des agents identifiés par lesdites méthodes de criblage. L'invention concerne également des méthodes de réduction d'une lésion du tissu ischémique ou d'une lésion causée par les radicaux libres dans un organe. Ces méthodes consistent généralement à placer l'organe au contact d'un agent qui augmente les niveaux et/ou l'activité de AldDH2. L'invention concerne en outre des méthodes de traitement de tumeurs solides, qui consistent généralement à administrer un agent qui diminue les niveaux et/ou l'activité de AldDH2.
Chen Che-Hong
Mochly-Rosen Daria
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
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